9th -12th Grade General Biology (with labs, activities organized by NGSS Performance Expectations as organized at NSTA/NGSS hub)


Short Cut to: Structure & Function, Inheritance & Variation of Traits, Matter and Energy in Organisms & Ecosystems, Interdependent Relationships in Ecosystems, Natural Selection & Evolution.

Direct link to All Podcasts / CrashCourse Biology and Computer Simulations/Games


Rubrics: Rubric for ADI write ups (link to reflection rubric How to write a “reflection” for a lab or activity (updated )


Basic Science Practices:

Lab Ideas

Activity Ideas

Supporting Podcasts, Articles, and Videos

Computer Modeling and Simulations

Celtic Stone Activity

Nature of Science Checks Activity (Student Instructions and Student Worksheet

Introduction to Scientific Inquiry: PillBug Sowbug Inquiry Lab What are Argument Driven Inquiry-based Lab-investigations? 2-part Investigation Form Example of a Sowbug Inquiry Write-up


Scientific Discover of your birth year

CER (claims-evidence-reasoning) ActivityWorksheet Peer Evaluation Sheet How to write a “reflection” for a lab or activity (updated ) CER (reading)

Writing in Biology PPT

Graphing Skills Practice this data

How to make a data table in Word

References and Pronouns to Avoid

Biology what's it all about

Lab safety w/puppets


How Science Really Works
The Real Scientific Method 

Sowbug/Pillbug Background

and More on Terrestrial Isopods




Structure & Function

HS-LS1-1: Construct an explanation based on evidence for how the structure of DNA determine the structure

of proteins which carry out the essential functions of life through systems of specialized cells

HS-LS1-2: Develop and use a model to illustrate the hierarchical organization of interacting systems that provide specific functions within multicellular organisms

HS-LS1-3: Plan and conduct an investigation to provide evidence that feedback mechanisms maintain homeostasis.


Lab Ideas

Activity Ideas

Supporting Podcasts, Articles, and Videos

Computer Modeling and Simulations

Microscope Rules ;Determining Field of View Strawberry DNA Isolation demonstration  

DNA to Protein

Protein Synthesis Worksheet 
DNA-Decoding Practice Sheet
DNA Messages 
DNA Message-Maker


Name that Gene


Case Study (Homeostasis) Nervous System Case Study: Bad Fish Bad Bird

Article: New sense of taste: Fat

Case Study (Homeostasis) Case Study: Chemical Eric a true story

Case Study: Resistance is futile??? (rubric)

Cold Scenario short activity

Cracking the Code of Life (streaming video)

Rosalind Franklin and Photo 51(transcript)

Interactive Animations DNA Replication

Great animation of DNA replication from DNAinteractive click on “copying the code”, then “putting it together” , then the “replication” button to see animations

Replication song to the backstreet boys

Great animation of DNA transcription from DNAinteractiveclick on “copying the code”, then “putting it together” , then the “transcription” button to see animations; there is also an interactive practice button

Great animation of DNA translation from DNAinteractiveclick on “reading the code”, then “putting it together” , then the “translation” button to see animations; there is also an interactive practice button

DNA Playing God (watch the video) (video questions)

Practicing transcribing and translating from gene to protein

Bacterial Genome Video

What are Plasmids Video

Video on Bacterial Transformation

Video on Gene Expression in Bacteria

LacOperon Info

the Teenage Brain (Frontline) link to online version

HIV  Viral Life Cycle NPR Virus Attack

Immune System/ HIV

Crash Course: Immune System

Build a Cell

Cell Craft

Cell Transport

Cell Defense the Plasma Membrane

Diffusion/Osmosis/Active Transport

Osmoregulation & Excretion

Membrane Formation



Eyewire*

Immune Attack

Code Fred-survival

Dizeez*

DNA to Protein


CSI the Experience

DNA Damage

Dragon Breeder Beta

Eterna*


Blood & Circulation

Virus Replication




Inheritance & Variation of Traits


HS-LS1-4: Use a model to illustrate the role of cellular division (mitosis) and differentiation in producing and maintaining complex organisms.

HS-LS3-1: Ask questions to clarify relationships about the role of DNA and chromosomes in coding the instructions for characteristic traits passed from parents to offspring.

HS-LS3-2: Make and defend a claim based on evidence that inheritable genetic variations may result from: (1) new genetic combinations through meiosis, (2) viable errors occurring during replication, and/or (3) mutations caused by environmental factors.

HS-LS3-3: Apply concepts of statistics and probability to explain the variation and distribution of expressed traits in a population.


Lab Ideas

Activity Ideas

Supporting Podcasts, Articles, and Videos

Computer Modeling and Simulations


Fast Plants: Mendelian Genetics Fast Plant Formal LabRubric Chi-Square Distribution Chart  alternate Chart

Onion Root Tutorial Activity: Onion Root tips

Cell Division Jeopardy

Chromonoodles (in a bag) (yarn meiosis 

Webquest meiosis 

I'm My Own Grandpaw

Harry Potter Genetics (PowerPoint #1#2if you have never read the books or seen the movies here is a short summary

Wizard of Odds(Background)  Complete: Magic Runs in Families Complex Traits and Hair Colors

Dragon Genetics  Design a Baby Dragon (worksheet)

Monster Genetics Activity

Genetics Problems Answer Sheet

Sex-linked 1, and 2 (challenging)

HHMI Genetics ActivitiesIntro Video

HHMI Sickle Cell Activity

Karotype and Non-disjunction Online Animation and Interactive Activity for Karyotyping Diagnose Genetic Disorders on Chromosomes

MendelianGenetics1MendelianGenetics2 

AlternateReading Colorblindness

ProblemDownSyndrome Problem

Simulated Blood Typing,

(Mitosis Rap and other activities)

Introduction to Mitosis in Plants and Animals (video )

Cells Alive Meiosis

Cold Spring Harbor/ Genetics

Resources for Meiosis:

Meiosis Practice



Pictures of Genetic Traits

Myths of Genetic Traits

the advantage to carrying Sickle cell trait

Intro Blood (ABO/Rh) (more ABO details if you're interested)

Rh incompatibility

Epigenetics and Survivors of the Holocaust

Ghost in Your Genes (Why your DNA isn't your destiny
More on Epigenetics:)


Dragon Breeding Laboratory

Probability Simulation



Matter & Energy in Organisms and Ecosystems


HS-LS1-5: Use a model to illustrate how photosynthesis transforms light energy into stored chemical energy

HS-LS1-6: Construct and revise an explanation based on evidence for how carbon, hydrogen, and oxygen from sugar molecules may combine with other elements to form amino acids and/or other large carbon-based molecules.

HS-LS1-7: Use a model to illustrate that cellular respiration is a chemical process whereby the bonds of food molecules and oxygen molecules are broken and the bonds in new compounds are formed resulting in a net transfer of energy.

HS-LS2 -3: Construct and revise an explanation based on evidence for the cycling of matter and flow of energy in aerobic and anaerobic conditions

HS-LS2-4: Use mathematical representations to support claims for the cycling of matter and flow of energy among organisms in an ecosystem.

HS-LS2-5: Develop a model to illustrate the role of photosynthesis and cellular respiration in the cycling of carbon among the biosphere, atmosphere, hydrosphere, and geosphere.


Lab Ideas

Activity Ideas

Supporting Podcasts, Articles, and Videos

Computer Modeling and Simulations

Lab 8: Enzymes: ADI

Building carbohydrates Biomolecule Worksheet

Testing biomolecules (animation)

Biomolecules-Organic form

CER article on enzymes (additional background information from Wikipedia)

Case Study: Case of Seven Deaths

Article:  Double Life of ATP

Article: Lactic Acid and Training 

Biology what's it all about  
Abiogenesis (creation of life from non-organic source) 

Origin of Life Evidence     

Origin of Life on Earth Sci Am Sept 2009

Life Not Life Activity (cards in file cabinet)

Abiotic synthesis

Panspermia

Miller/Urey (experiment)

Podcast on pH, all you would want to know (13 minutes)

Podcast Ionic vs Covalent Bonds

Podcast Water: Polar Covalent

Animation of building Biomolecules

Amino Acids & Proteins

Cellular Respiration Song (Black Eyed Peas)

TCA Cycle (Krebs)

Electron Transport Chain

Interactive Animations of Photosynthesis

  ATP Synthase movie 

Macromolecules Gangnam Style

Chemisomosis

cool video of mitochondria

Light-dependent animation

Calvin Cycle animation

Leaf Photosynthesis NetLogo Model

Cellular Respiration

Chemical Bonds

Seeing Intramolecular Attraction

Intramolecular Attraction

Tree of Life and Molecules

Molecular Self AssemblyBuilding Proteins & Function

Games: Biochem Gems

Chemical Bonds

Seeing Intramolecular Attraction

Intramolecular Attraction*

Gas Laws*

Tree of Life and Molecules

Molecular Self Assembly




Interdependent Relationships in Ecosystems


HS-LS2-1: Use mathematical and/or computational representations to support explanations of factors that affect carrying capacity of ecosystems at different scales.

HS-LS2-2: Use mathematical representations to support and revise explanations based on evidence about factors affecting biodiversity and populations in ecosystems of different scales

HS-LS2-6: Evaluate the claims, evidence, and reasoning that the complex interactions in ecosystems maintain relatively consistent numbers and types of organisms in stable conditions, but changing conditions may result in a new ecosystem.

HS-LS2-7: Design, evaluate, and refine a solution for reducing the impacts of human activities on the environment and biodiversity

HS-LS2-8: Evaluate the evidence for the role of group behavior on individual and species’ chances to survive and reproduce.

HS-LS4-6: Create or revise a simulation to test a solution to mitigate adverse impacts of human activity on biodiversity.



Lab Ideas

Activity Ideas

Supporting Podcasts, Articles, and Videos

Computer Modeling and Simulations


What are dichotomous keys? Dichotomous Key PPT and Instructions for Lab activity


Biodiversity Project California Biodiversity Action Plan & Rubrics

What did T-Rex Taste Like Activity

Classification Tutorial Lecture PPT of Animal Diversity (14 MB)


Shape of Life/Life on the Flatworms you can find these episodes in several parts on YouTube)

Shape of Life:/Echinoderms (onYouTube, in several parts)

Shape of Life: Bones, Brawn & Brains (on YouTube in several parts)


Gulf Oil spill 5 years later




Happy Match

Modeling Climate

Will there be enough fresh water?

Population Explosion

Global Carbon Budget*

Climate Change




Natural Selection & Evolution


HS-LS4-1: Communicate scientific information that common ancestry and biological evolution are supported by multiple lines of empirical evidence.

HS-LS4-2: Construct an explanation based on evidence that the process of evolution primarily results from four factors: (1) the potential for a species to increase in number, (2) the heritable genetic variation of individuals in a species due to mutation and sexual reproduction, (3) competition for limited resources, and (4) the proliferation of those organisms that are better able to survive and reproduce in the environment.

HS-LS4-3: Apply concepts of statistics and probability to support explanations that organisms with an advantageous heritable trait tend to increase in proportion to organisms lacking this trait.

HS-LS4-4: Construct an explanation based on evidence for how natural selection leads to adaptation of populations.

HS-LS4-5: Evaluate the evidence supporting claims that changes in environmental conditions may result in: (1) increases in the number of individuals of some species, (2) the emergence of new species over time, and (3) the extinction of other species


Lab Ideas

Activity Ideas

Supporting Podcasts, Articles, and Videos

Computer Modeling and Simulations

Evolutionary Relationships in Mammals (Genetics and Evolution)

Color Variation over Time in Rock Pocket Mouse Populations


Crime scene lab powerpoint

Crime scene instructions powerpoint

Instructions PPT

DNA Scissors

DNA goes to the Races

Modified Procedure  2012

Crime Scene

Gels and Electrophoresis

Semi-log paper  and data table and questions  




Stickleback Activity

Breeding Bunnies (NetLogo version)

Heterozygous Advantage (NetLogo version)

Molecular Genetics of Color Mutations in Rock Pocket Mice (HHMI)

Natural Selection in Rock Pocket Mice (HHMI)



Lab Introduction and Instructions for Lengthy Relationships & How Tall were They

Lengthy Relationships 

Footsteps in Time

Laetoli Footprint

Laetoli Trackways Diagram (additional information: Laetoli topo 1,Laetoli topo 2southern track topoquestions


Human Evolution PPT Introduction to Hominin Skull Lab (ppt)
Hominid Skull Activity
Comparing Primate Skeletons


Close Reading Claims-evidence-reasoning activity: Who came before Lucy activity 


 OJ Simpson case  Updated Video from BBC Article Activity on DNA technology





Biology what's it all about 
Abiogenesis (creation of life from non-organic source)  Origin of Life Evidence   


What Darwin Never Knew

Great Transformations (from Evolution Series)

Evolution: The Evolutionary Arms Race 

Evolution Video: Why Sex

Quest: Finding Darwin; Chasing Beetles


Human Evolution Becoming Human  Becoming Human (check out the 3-D skulls, they rotate)

Fossil Horses in Cyberspace

New Homind Species Red Deer Cave People?

Evolutionary Evidence that birds descended from dinosaurs


Evolution of the Eye (to see whole program in sections


The Embarrassing History of Eugenics in the US


Forensics on Trial Podcast on DNA Fingerprint copying/Profiling

Genomics Digital Lab

Mission Biotech

Dragon Breeder Beta

Conflicting Selection Pressure

Pepper Moth